Dornase alfa is a mucolytic medication used in the treatment of cystic fibrosis. By cutting apart extracellular DNA, it makes mucus thinner.
- Genentech. (2018). How Pulmozyme works. [online] Available at: http://www.pulmozyme.com/how-pulmozyme-CF-treatment-works [Accessed 20 Jan. 2018].
- Yang, C., Chilvers, M., Montgomery, M., & Nolan, S. J. (2016). Dornase alfa for cystic fibrosis. The Cochrane Database of Systematic Reviews, 4, CD001127.
Surfactant is produced by type 2 pneumocytes.
How can this be remembered?
Because surfactant has 2 ts in it.
People usually have 2 lungs, too.
Isn’t learning fun?
Yes, it is.
- BioNinja. (2017). Pneumocytes | BioNinja. [online] Available at: http://ib.bioninja.com.au/standard-level/topic-6-human-physiology/64-gas-exchange/pneumocytes.html [Accessed 26 Aug. 2017].
Both are fluids that can occur in the body during inflammation or changes in liquid-solid (oncotic-hydrostatic) pressures.
Transudate is transparent, because it is clear and has a low protein content. It comes from a deranged balance of oncotic-hydrostatic pressures. As a generalisation, think systemic disease.
Exudate involves extruded proteins. It has a comparatively high protein content. As a generalisation, think local inflammation or malignancy.
A pleural effusion can involve transudate or exudate. Light’s Criteria is used to determine which is the case.
- Exeter Clinical Laboratory. Blood Sciences Test / Transudate or Exudate. Retrieved 19 March 2017, from http://www.exeterlaboratory.com/test/transudate-or-exudate/
- Life in the Fast Lane Medical Blog. Pleural Fluid Analysis. Retrieved 19 March 2017, from https://lifeinthefastlane.com/investigations/pleural-fluid-analysis/
- American Family Physician. (2006). Diagnostic Approach to Pleural Effusion in Adults. Retrieved 19 March 2017, from http://www.aafp.org/afp/2006/0401/p1211.html