Dornase Alfa

Dornase alfa is a mucolytic medication used in the treatment of cystic fibrosis. By cutting apart extracellular DNA, it makes mucus thinner.

References

  1. Genentech. (2018). How Pulmozyme works. [online] Available at: http://www.pulmozyme.com/how-pulmozyme-CF-treatment-works [Accessed 20 Jan. 2018].
  2. Yang, C., Chilvers, M., Montgomery, M., & Nolan, S. J. (2016). Dornase alfa for cystic fibrosis. The Cochrane Database of Systematic Reviews, 4, CD001127.
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Lung Surfactant

Surfactant is produced by type 2 pneumocytes.

How can this be remembered?

Because surfactant has 2 ts in it.

People usually have 2 lungs, too.

Isn’t learning fun?

Yes.

Yes, it is.

References

  1. BioNinja. (2017). Pneumocytes | BioNinja. [online] Available at: http://ib.bioninja.com.au/standard-level/topic-6-human-physiology/64-gas-exchange/pneumocytes.html [Accessed 26 Aug. 2017].

Transudate Versus Exudate

Both are fluids that can occur in the body during inflammation or changes in liquid-solid (oncotic-hydrostatic) pressures.

Memory aids

Transudate is transparent, because it is clear and has a low protein content. It comes from a deranged balance of oncotic-hydrostatic pressures. As a generalisation, think systemic disease.

Exudate involves extruded proteins. It has a comparatively high protein content. As a generalisation, think local inflammation or malignancy.

Pleural effusions

A pleural effusion can involve transudate or exudate. Light’s Criteria is used to determine which is the case.

References

  1. Exeter Clinical Laboratory. Blood Sciences Test / Transudate or Exudate. Retrieved 19 March 2017, from http://www.exeterlaboratory.com/test/transudate-or-exudate/
  2. Life in the Fast Lane Medical Blog. Pleural Fluid Analysis. Retrieved 19 March 2017, from https://lifeinthefastlane.com/investigations/pleural-fluid-analysis/
  3. American Family Physician. (2006). Diagnostic Approach to Pleural Effusion in Adults. Retrieved 19 March 2017, from http://www.aafp.org/afp/2006/0401/p1211.html