Trivia About PTH

Just like everybody knows that Andrew Garfield is the best-looking Spider-Man ever, everybody knows what PTH does.

Obviously! Your local supermarket worker knows it! Your angry ex-partner who’s now filing for asset claims from you knows it! The door-knocking salesperson you try to hide from by pretending you’re not at home when they try to pester you knows it!

Parathyroid hormone, affectionately referred to as PTH, is renowned for its action of freeing calcium from bones. But does it do this through osteoclasts directly? After all, osteoclasts eat bone and osteoblasts build bone.

The answer is…

No.

NO.

NO!

PTH indirectly stimulates osteoclasts to resorb bone. Mind-blowingly, it does this through osteoblasts.

References

  1. University Of Washington. (2017). Bone Remodeling. [online] Available at: https://courses.washington.edu/conj/bess/bone/bone2.html [Accessed 30 Jul. 2017].
  2. Zhao, W., Byrne, M. H., Boyce, B. F., & Krane, S. M. (1999). Bone resorption induced by parathyroid hormone is strikingly diminished in collagenase-resistant mutant mice. Journal of Clinical Investigation, 103(4), 517–524. Available at: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC408105/ [Accessed 30 Jul. 2017].
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