Stimulates bone formation

Wnt: Wow! Let’s have bone formation!

Wnt proteins bind to LRP5 receptors on osteoblasts, triggering bone formation.

Inhibits bone formation

Sclerostin: Stop! No bone formation here!

Sclerostin is a factor produced by osteocytes. It inhibits the above Wnt process.

References

1. Walker, B. R., Colledge, N. R., Ralston, S., & Penman, I. D. (2014;2013;). Davidson’s principles and practice of medicine (22nd ed.). Edinburgh: Churchill Livingstone/Elsevier.